Traditional food beats chemotherapy for cancer

Traditional food beats chemotherapy for cancer

Traditional food beats chemotherapy for cancer

A traditional food beats chemotherapy for cancer, according to a new study from the journal Molecular and Cellular Biochemistry.

According to the American Cancer Society (ACS), lung cancer is the second most common type of cancer in both men and women. About 14% of all new cancers are lung cancers. The ACS estimates 224,390 new cases of lung cancer in 2016 and about 158,080 deaths.

In comes the Noni leaf. The new study shows that Noni leaves may be the ideal complementary therapeutic food to prevent or manage lung cancer. The study found that the extract from this Noni leaf performed better than a chemotherapy drug.

The study abstract explained the following methods and results:

Metastasized lung and liver cancers cause over 2 million deaths annually, and are amongst the top killer cancers worldwide. Morinda citrifolia (Noni) leaves are traditionally consumed as vegetables in the tropics. The macro and micro effects of M. citrifolia (Noni) leaves on metastasized lung cancer development in vitro and in vivo were compared with the FDA-approved anti-cancer drug Erlotinib. The extract inhibited the proliferation and induced apoptosis in A549 cells (IC50 = 23.47 μg/mL) and mouse Lewis (LL2) lung carcinoma cells (IC50 = 5.50 μg/mL) in vitro, arrested cancer cell cycle at G0/G1 phases and significantly increased caspase-3/-8 without changing caspase-9 levels. The extract showed no toxicity on normal MRC5 lung cells. Non-small-cell lung cancer (NSCLC) A549-induced BALB/c mice were fed with 150 and 300 mg/kg M. citrifolia leaf extract and compared with Erlotinib (50 mg/kg body weight) for 21 days. It significantly increased the pro-apoptotic TRP53 genes, downregulated the pro-tumourigenesis genes (BIRC5, JAK2/STAT3/STAT5A) in the mice tumours, significantly increased the anti-inflammatory IL4, IL10 and NR3C1 expression in the metastasized lung and hepatic cancer tissues and enhanced the NFE2L2-dependent antioxidant responses against oxidative injuries. The extract elevated serum neutrophils and reduced the red blood cells, haemoglobin, corpuscular volume and cell haemoglobin concentration in the lung cancer-induced mammal. It suppressed inflammation and oedema, and upregulated the endogenous antioxidant responses and apoptotic genes to suppress the cancer. The 300 mg/kg extract was more effective than the 50 mg/kg Erlotinib for most of the parameters measured.

One of the most notable findings in the study is that the Noni leaf exhibited no toxicity to healthy lung cells, which is something that chemotherapy and radiation treatments can’t claim.

The study showing that traditional food beats chemotherapy for cancer was published in the journal Molecular and Cellular Biochemistry.

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REFERENCES:
1. “Traditional Food Puts Chemotherapy To Shame, New Study Reveals.” GreenMedInfo.com. GreenMedInfo.com, n.d. Web. 25 May 2016.
2. “Metastasized Lung Cancer Suppression by Morinda Citrifolia (Noni) Leaf Compared to Erlotinib via Anti-inflammatory, Endogenous Antioxidant Responses and Apoptotic Gene Activation.” National Center for Biotechnology Information. U.S. National Library of Medicine, n.d. Web. 25 May 2016.
3. “Key Statistics for Lung Cancer.” American Cancer Society. American Cancer Society, n.d. Web. 25 May 2016.

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